David Tsai

NHMRC CJ Martin Biomedical Fellow


Email: dsai@ee.columbia.edu

Ph.D., Biomedical Engineering, University of New South Wales, 2012
M. BiomedE., University of New South Wales, 2007
B.E. (Hons 1st class), University of New South Wales, 2007

I work at the junction between engineering and neuroscience. My present research include:

  1. CMOS multielectrode array technologies and analytical systems for large-scale, simultaneous recording and stimulation of neuronal population.
  2. Understanding the computational principles of the retina, through a combination of research tools: electrophysiology, imaging, and computational simulation.

More about me.

Journals

  • D Tsai, R Yuste, K L Shepard, Statistically reconstructed multiplexing for very dense, high-channel-count acquisition systems, IEEE Transactions on Biomedical Circuits and Systems. 2018(12) 13-23, DOI: 10.1109/TBCAS.2017.2750484.
  • D Tsai, D Sawyer, A Bradd, R Yuste, K L Shepard, A very large-scale microelectrode array for cellular-resolution electrophysiology, Nature Communications, 2017(8) 1802. [pubmed].
  • D Tsai, J W Morley, G J Suaning, N H Lovell, Survey of electrically evoked responses in the retina – stimulus preferences and oscillation among neurons, Scientific Report, 2017(7) 13802 1. [pubmed].
  • K Jayant, J Hirtz, I J Plante, D Tsai, W De Boer, A Semonche, D Peterka, J Owen, O Sahin, K Shepard, R Yuste, Targeted intracellular voltage recordings from dendritic spines using quantum-dot coated nanopipettes, Nature Nanotechnology, 2016(12) 335-3342. [pubmed].
  • T Guo, D Tsai, J W Morley, G J Suaning, T Kameneva, N H Lovell, S Dokos, Electrical Activity of ON and OFF Retinal Ganglion Cells: A Modelling Study, Journal of Neural Engineering, 2016(13) 025005, [pubmed].
  • J Choi, E Aklimi, C Shi, D Tsai, H Krishnaswamy, K L Shepard, Matching the power, voltage, and size of biological systems: a nW-scale, 0.023-mm3 pulsed 33-GHz radio transmitter operating from a 5kT/q-supply voltage, IEEE Transactions on Circuits and Systems, 2015(62) 1950–1958, [IEEE Explore].
  • T Gou, D Tsai, J W Morley, G J Suaning, N H Lovell, S Dokos, Understanding the retina: a review of computational models of the retina from the single-cell to network level, Critical Reviews in Biomedical Engineering, 2014(42) 419-436 [pubmed].
  • P B Matteucci, S C Chen, D Tsai, C W Dodds, S Dokos, J W Morley, N H Lovell, G J Suaning, Current steering in retinal stimulation via a quasimonopolar stimulation paradigm, Investigative Ophthalmology & Visual Science , 2013(54) 4307-4320, [pubmed].
  • D Tsai, S C Chen, D A Protti, J W Morley, G J Suaning, N H Lovell, Responses of retinal ganglion cells to extracellular electrical stimulation from single cell to population: model-based analysis, PLoS ONE, 2012(7) e53357. [pubmed].
  • D Tsai, J W Morley, G J Suaning, N H Lovell, Frequency–dependent reduction of voltage-gated sodium channels modulates retinal ganglion cell response rate to electrical stimulation, Journal of Neural Engineering, 2011(8) 066007, (featured article). [pubmed].
  • D Tsai, J W Morley, G J Suaning, N H Lovell, Direct Activation and Temporal Response Properties of Rabbit Retinal Ganglion Cells Following Subretinal Stimulation, Journal of Neurophysiology, 2009(102) 2982–2993 (cover article). [pubmed].
  • D Tsai, J W Morley, G J Suaning, N H Lovell, A wearable real–time image processor for a vision prosthesis, Computer Methods and Programs in Biomedicine, 2009(95) 258–269. [pubmed].

Peer reviewed proceedings

  • T Guo, A Barriga-Rivera, G Suaning, D Tsai, S Dokos, J W Morley, N H. Lovell, Mimicking natural neural encoding through retinal electrostimulation, Proceedings of the 8th International IEEE EMBS Conference on Neural Engineering, 2017 284-287 (4 pages).
  • D Tsai, E John, T Chari, R Yuste, K L Shepard, High-channel-count, high-density microelectrode array for closed-loop investigation of neuronal networks, Proceedings of the 37th Annual International Conference of the IEEE EMBS, 2015 (4 pages). (Best 10 papers, with JBHI invitation).
  • C Yang, A Woolley, D Tsai, G J Suaning, J W Morley, N H Lovell, Calcium imaging of retinal ganglion cell dendritic responses to extracellular microelectrode stimulation, Proceedings of the 7th International IEEE EMBS Conference on Neural Engineering, 2015 (4 pages).
  • T Guo, N H Lovell, D Tsai, P Twyford, S Fried, J W Morley, G J Suanning, S Dokos, Optimizing retinal ganglion cell responses to high-frequency electrical stimulation strategies for preferential neuronal excitation, Proceedings of the 7th International IEEE EMBS Conference on Neural Engineering, 2015 (4 pages).
  • S Bai, T Guo, D Tsai, J W Morley, G J, Suanning, N H Lovell, S Dokos, Influence of retinal ganglion cell morphology on neuronal response properties: a simulation study, Proceedings of the 7th International IEEE EMBS Conference on Neural Engineering, 2015 (4 pages).
  • J Choi, E Aklimi, J Roseman, D Tsai, H Krishnaswamy, K L Shepard, Matching the power density and potentials of biological systems: a 3.1-nW, 130-mV, 0.023-mm3 pulsed 33-GHz radio transmitter in 32-nm SOI CMOS, Proceedings of the IEEE Custom Integrated Circuits Conference, 2014.
  • T Gou, N H Lovell, D Tsai, P. Twyford, S. Fried, J W Morley, G J Suaning, S Dokos, Selective activation of ON and OFF retinal ganglion cells to high-frequency electrical stimulation: A computational modeling study, Proceedings of the 36th Annual International Conference of the IEEE EMBS, 2014 (4 pages). (Student paper competition Asia-Pacific finalist).
  • T Guo, D Tsai, J W Morley, G J Suaning, N H Lovell, S Dokos, Cell-specific modeling of retinal ganglion cell electrical activity, Proceedings of the 35th Annual International Conference of the IEEE EMBS, 2013 accepted (4 pages) (Student paper competition finalist).
  • T Guo, D Tsai, S. Sovilj, J W Morley, G J Suaning, N H Lovell, S Dokos, Influence of active dendrites on firing patterns in a retinal ganglion cell model, Proceedings of the 35th Annual International Conference of the IEEE EMBS, 2013 accepted (4 pages).
  • T Guo, D Tsai, J W Morley, G J Suaning, N H Lovell, S Dokos, Influence of cell morphology in a computational model of ON and OFF retinal ganglion cells, Proceedings of the 35th Annual International Conference of the IEEE EMBS, 2013 accepted (4 pages).
  • T Guo, D Tsai, N H Lovell, S Dokos, Modeling Normal and Rebound excitation in Mammalian Retinal Ganglion Cells, Proceedings of the 34th Annual International Conference of the IEEE EMBS, 2012 (4 pages).
  • D Tsai, J W Morley, G J Suaning, N H Lovell, Responses of starburst amacrine cells to prosthetic stimulation of the retina, Proceedings of the 33rd Annual International Conference of the IEEE EMBS, 2011 (4 pages).
  • D Tsai, J W Morley, G J Suaning, N H Lovell, Sodium channel inactivation reduces retinal ganglion cell responsiveness to repetitive prosthetic stimulation, The 5th international IEEE EMBS Conference on Neural Engineering, 2011 (4 pages).
  • G J Suaning, S Kisban, S C Chen, P J Byrnes-Preston, C Dodds, D Tsai, P Matteucci, S Herwik, J W Morley, N H Lovell, O Paul, T Stieglitz, P Ruther, Discrete Cortical Responses from Multi–site Supra–Choroidal Electrical Stimulation in the Feline Retina, Proceedings of the 32nd Annual International Conference of the IEEE EMBS, Buenos Aires, 2010 (4 pages).
  • D Tsai, J W Morley, G J Suaning, N H Lovell, Direct Activation of Retinal Ganglion Cells with Subretinal Stimulation, Proceedings of the 31st Annual International Conference of the IEEE EMBS, 2009 (4 pages).

Conferences

  • D Tsai, K Shepard, CMOS Neuroprobes, Materials Research Society (MRS) Spring Meeting 2017, Phoenix Arizona, Apr. 2017.
  • J W Morley, C-Y Yang, D Tsai, T Guo, G Suaning, S Dokos, N H Lovell, High Frequency Electrical Stimulation: the Effect of Spatial Location on Retinal Ganglion Cell Responses In Vitro, Neuroscience 2016, San Diego CA, USA, 2016.
  • K Jayant, J J Hirtz, I J-L Plante, D T Tsai, W D Boer, A Semonche, D Peterka, J S Owen, O Sahin, K L Shepard, R Yuste, Direct electrical recordings from dendritic spines using nano-pipettes, Neuroscience 2015, Chicago IL, USA, 2015.
  • D Tsai, E John, R Yuste, K L Shepard, Advancing the state-of-the-art in electrophysiology: pushing the limits on amplifier density, IEEE EMBS BRAIN Grand Challenges Conference, Washington DC, USA, 2014.
  • T Guo, D Tsai, G J Suaning, N H Lovell S Dokos, Influence of dendritic structure on retinal ganglion cell firing pattern: a modeling study, NeuroEng 2013: 6th Australian Workshop on Computational Neuroscience, Melbourne, Australia (NeuroEng student prize).
  • D Tsai, J W Morley, G J Suaning, N H Lovell, Temporal response profiles of amacrine cells following electrical stimulation of the retina, Neuroscience 2011, Washington DC, USA, 2011.
  • D Tsai, J W Morley, G J Suaning, N H Lovell, Activation of voltage-gated ion channels in rabbit retinal ganglion cells following electrical stimulation of the retina, Australian Neuroscience Society Meeting 2011, Auckland New Zealand, 2011.
  • D Tsai, J W Morley, G J Suaning, N H Lovell, Inactivation of sodium current modulates retinal ganglion cell response rate during high frequency stimulation, Neuroscience 2010, San Diego USA, 2010.
  • V Tatarinoff, D Tsai, How Deep is deep Enough? Australian and New Zealand Laboratory Animal Association Conference, 2010 (Best presentation award).
  • D Tsai, J W Morley, G J Suaning, N H Lovell, Retinal ganglion cell responses following subretinal electrical stimulation in the isolated rabbit retina, Neuroscience 2009, Chicago USA, 2009.

Patents

  • D Tsai, J W Morley, G J Suaning, N H Lovell, Stimulation method for maintaining the responsiveness of electrically excitable cells to repeated electrical stimulation. US Patent Office. Patent No. 9,669,213 B2.
  • D Tsai, J W Morley, G J Suaning, N H Lovell, Stimulation method for maintaining the responsiveness of electrically excitable cells to repeated electrical stimulation. Australian Patent Office. Patent No. 2012211030.
  • D Tsai, J W Morley, G J Suaning, N H Lovell, Stimulation method for maintaining the responsiveness of electrically excitable cells to repeated electrical stimulation. European. Pub No: WO/2012/100290.
  • K Shepard, D Tsai, H Kang, J Thimot, Flexible complementary metal-oxide-semiconductor probes for chronic, large-scale neural stimulation and recording, US Patent Office, Provisional Application 62/210,532.
  • D Tsai, Jonathan Terry, K Shepard, Fully implanted, wireless, flexible CMOS surface recording device for the brain, US Patent Office, Provisional Application.
  • D Tsai, K Shepard, Systems and methods for dense, high-channel-count, multichannel data acquisition, US Patent Office, Provisional Application.